Novel role for β-adrenergic signalling in skeletal muscle growth, development and regeneration: Proceedings of the Australian physiological society symposium: Signals mediating exercise-induced skeletal muscle remodelling

JG Ryall; JE Church; GS Lynch

Journal article

Novel role for β-adrenergic signalling in skeletal muscle growth, development and regeneration: Proceedings of the Australian physiological society symposium: Signals mediating exercise-induced skeletal muscle remodelling

JG Ryall, JE Church, GS Lynch

Clinical and Experimental Pharmacology and Physiology | Published : 2010

DOI: 10.1111/j.1440-1681.2009.05312.x

Abstract

In adult mammals, skeletal muscle mass is maintained through a precise balance of protein synthesis and protein degradation, whereas during development cellular (not protein) turnover predominates. When protein balance is shifted towards synthesis, skeletal muscle hypertrophy ensues. In contrast, increased protein degradation leads to skeletal muscle atrophy. Insulin-like growth factor (IGF)-I is among the best documented of the growth factors and regulates skeletal muscle mass by increasing protein synthesis and decreasing protein degradation. However, an IGF-I-independent growth pathway has been identified that involves the activation of β-adrenoceptors and subsequent skeletal muscle growt..

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University of Melbourne Researchers

Gordon Lynch Author

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Grants

Awarded by Australian Research Council

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by Muscular Dystrophy Association (Tucson, AZ, USA)

Funding Acknowledgements

The authors are grateful for research grant funding from the Australian Research Council Discovery-Project funding scheme (DP0665071, DP0772781), the National Health and Medical Research Council of Australia (NHMRC; 454561, 509313), the Muscular Dystrophy Association (Tucson, AZ, USA; 4167) and Pfizer Inc. (New York, NY, USA). JGR is supported by a Biomedical Overseas Research Fellowship from the NHMRC (520034).